THE USE OR THOREMIPHEN AND ITS METABOLITES FOR THE ELIMINATING OF THE RESISTENCY OF CANCER CELLS AGAINST CYTOTOXIC PHARMACEUTICALS

摘要

A compound comprising toremifene or its metabolite N-demethyltoremifene or 4-hydroxytoremifene, or a non-toxic pharmaceutically acceptable salt thereof may be used for the reversal of multidrug resistance of cancer cells to cytotoxic drugs in the treatment of cancer with at least one cytotoxic drug.