发明名称 |
PROCESS FOR PRODUCING RECOMBINANT GAMMA-INTERFERONOK OF IMPROVED STABILITY AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME |
摘要 |
Provided are methods for the production of mixtures of interferon (IFN)- gamma polypeptides. The methods employ a single species of IFN- gamma DNA having codons for Met-Gln and for residues 2-143 of the mature human IFN- gamma amino acid sequence. Expression of such DNA in a suitable recombinant host cell affords a mixture of polypeptides having N-terminal Met-Gln, H-Gln, or H-pyroglutamate residues and C-termini at Arg139, Ser142, or Gln143 of the mature IFN- gamma sequence. The polypeptides so produced exhibit the antiviral and antiproliferative activities as well as the acid lability characteristic of native human IFN- gamma . |
申请公布号 |
HU202278(B) |
申请公布日期 |
1991.02.28 |
申请号 |
HU19840004669 |
申请日期 |
1984.12.14 |
申请人 |
GENENTECH INC.,US |
发明人 |
GRAY,PATRICK WILLIAM,US;RINDERKNECHT,ERNST HEINRICH,US |
分类号 |
C12N15/09;A61K38/00;A61K38/21;A61P35/00;A61P43/00;C07H21/04;C07K1/20;C07K14/00;C07K14/52;C07K14/555;C07K14/57;C12N1/00;C12N1/21;C12N5/00;C12N5/10;C12N15/00;C12N15/20;C12N15/23;C12P21/00;C12P21/02;C12R1/19;C12R1/91 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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