发明名称 |
Novel antigens and methods for their preparation. |
摘要 |
<p>A composite particle comprising at least two polypeptides corresponding to all or part of a protein having the biological activity of one of the hepatitis B surface antigens, wherein the particle presents at least two antigenic determinants provided by the S-protein, preS2-protein or preS1-protein, said particle optionally further comprising host specific lipids. The invention also provides a modified hepatitis B surface antigen L protein which may be used alone or incorporated into such composite particles. A particular embodiment of the modified L protein (L*) comprises residues 12-52 followed by residues 133-145 followed by residues 175-400 of the L protein and a particular embodiment of a composite particle has the form (L*, S) where S is the S-protein of HBsAg. Improved hepatitis B vaccines may be prepared following expression of the above immunogens, especially in yeasts such as S. cerevisiae and Hansenula polymorpha.</p> |
申请公布号 |
EP0414374(A2) |
申请公布日期 |
1991.02.27 |
申请号 |
EP19900307900 |
申请日期 |
1990.07.19 |
申请人 |
SMITHKLINE BIOLOGICALS S.A. |
发明人 |
COMBERBACH, MARTIN;HARFORD, NIGEL;CABEZON, TERESA;RUTGERS, APOLONIA;VOET, PIERRE;JACOBS, ERIC;HOLLENBERG, CORNELIS P.;JANOWICZ, ZBIGNIEW A.;MERCKELBACH, ARMIN J. |
分类号 |
A61K39/00;A61K39/29;C07K1/22;C07K14/00;C07K14/02;C07K14/10;C07K14/18;C07K14/705;C12N1/19;C12N7/04;C12N15/09;C12N15/36;C12N15/81;C12P21/02;C12R1/78;C12R1/865;C12R1/92 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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