| 摘要 |
<p>17 beta -Acyl-4-aza-5 alpha -androst-1-ene-3-ones of the formula: <CHEM> wherein R is selected from hydrogen, methyl and ethyl and R<2> is monocyclic aryl optionally containing 1 or more lower alkyl substituents of from 1-2 carbon atoms and/or 1 or more halo (Cl or Br) substituents; and R min , R sec and R''' are each selected from hydrogen and methyl and pharmaceutical formulation of the above compounds are active as testosterone 5 alpha -reductase inhibitors and thus are useful for treatment of acne, seborrhea, female hirsutism, androgenic alopecin, prostatic carcinoma and benign prostatic hypertrophy.</p> |
