发明名称 |
STABILIZED PROTEIN OR PEPTIDE CONJUGATES |
摘要 |
A process for extending the half-life in vivo by a biologically active protein or peptide, characterized by covalently coupling said protein or peptide to a polypeptide fragment capable of binding to a serum protein, whereby when administering the resulting protein or peptide congugate its binding to the serum protein results in extended biological activity; the use of the protein or peptide conjugate above for manufacturing a medicament which, when administered to a mammal including man, shows extended half-life in vivo; and a method of therapeutic or prophylactic treatment. |
申请公布号 |
WO9101743(A1) |
申请公布日期 |
1991.02.21 |
申请号 |
WO1990SE00509 |
申请日期 |
1990.07.31 |
申请人 |
CEMU BIOTEKNIK AB |
发明人 |
NYGREN, PER-AAKE;WIGZELL, HANS;UHLEN, MATHIAS |
分类号 |
A61K38/00;A61K39/00;A61K39/395;A61K47/48;C07K14/00;C07K14/195;C07K14/31;C07K14/41;C07K14/76;C07K19/00;C12N15/09;C12N15/62;C12P21/00;C12R1/19 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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