| 摘要 |
<p>A method for the detection of multiple drug-resistant tumor cells is described which comprises the admixture of a sample of mammalian tumor cellular material with an effective binding amount of a labeled colchicine derivative to form a complex with any P-gp that is present, and then determining the amount of P-gp present by quantitating the amount of labeled colchicine derivative bound to P-gp. Photoaffinity and radiolabeled derivatives of colchicine and the syntheses of such derivatives are described, as are a method of treatment for multiple drug-resistant tumors and a diagnostic kit.</p> |
