发明名称 |
PHENYL-GLYCINE DERIVATIVES |
摘要 |
<p>Process for the preparation of compounds (I), wherein A and R<2> are defined as in Claim 1, by reaction of phenyl-glycine (VII) in the presence of alkanol with 1.05-1.3 moles of alkali hydroxide and reacting the mixture with an acid with a higher pH value than 4.3, or by reaction of (VII) with an equivalent amount of alkali salts of acids possessing a higher pH value than 4.3, and condensing the obtained amino acid salt in the presence of alkanol with a compound (VIII) -R<1> is defined as in Claim 1- at the boiling point of the reaction mixture, removing water continuously from the reaction mixture by a binary or ternary azeotropic distillation. The thus obtained compound is optionally reacted with a reactive trifluoro-methane sulphonic acid derivative.</p> |
申请公布号 |
WO9101969(A1) |
申请公布日期 |
1991.02.21 |
申请号 |
WO1990HU00052 |
申请日期 |
1990.07.25 |
申请人 |
CHINOIN GYOGYSZER- ES VEGYESZETI TERMEKEK GYARA RT |
发明人 |
BAN, KAROLY;BAN, ANNAMARIA;PALI, LAJOSNE;KRUPPA, MARTA;SOMFAI, EVA;HUSZAR, CSABA |
分类号 |
C07C227/18;C07C309/00;C07D307/58 |
主分类号 |
C07C227/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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