| 摘要 |
Antihistamines of the formula <IMAGE> wherein <IMAGE> is a 5 or 6 membered ring which is phenyl or heterocyclic; <IMAGE> is a six membered ring which is 2,3 or 4 pyridyl or is phenyl or substituted phenyl, with the proviso that is <IMAGE> is a nitrogen containing ring, <IMAGE> must be phenyl; Z is an alkylene chain having 0 to 2 carbon atoms in the chain, said 2 carbon chain optionally having one double bond, said chain optionally having either a carbonyl oxygen, or a hydroxy group as a substituent; W is <IMAGE> +TR <IMAGE> wherein p is 1 or 2 and n is 1 or 2, R1 is C1 to C6 alkyl, R2 is hydrogen or C1 to C6 alkyl, and the dotted line represents an optical double bond, R2 being absent if the double bond is present, and Y is substituted carboxylate or substituted sulfonyl. Said antihistamines have little or no sedative effects.
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