| 摘要 |
1,269,987. Antacid compositions. G. R. BROWN. 14 April, 1969 [18 April, 1968; 20 Dec., 1968], No. 19070/69. Heading A5B. An antacid composition comprises an antacid and at least one pharmaceutically acceptable gelation agent which is a waterdispersible colloidal anionic ether and/or ester of a polymer of a monosaccharide, wherein the gelation agent and the antacid are selected and the proportion thereof are such that: (1) the composition contains a major proportion of antacid and a minor proportion of gelation agent based on the combined total weight of the antacid and gelation agent in the composition, (2) the composition, when prepared in aqueous suspension so as to attain a viscosity of 300 cps. at 25‹C, must be capable of containing a greater total antacid-solids concentration than that attainable without inclusion of gelation agents, and, (3) upon the progressive addition of less than 2 cc. increments of phosphate solution, having the composition defined below, per 100 grams of an aqueous suspension of fluid consistency of the formulation meeting the criteria 1 and 2, an increase in viscosity to a viscosity greater than the initial viscosity of the suspension of fluid consistency is obtained, said phosphate solution prepared by dissolving 41.6 gm. of Na 3 PO 4 .12H 2 O and 55.3 gm. NaH 2 PO 4 .H 2 O is approximately 25 ml. of hot distilled water and diluting the resulting solution to a 100 ml. volume. The composition may also contain other therapeutic substances such as anti-spasmodics, e.g. dicyclomine hydrochloride or atropine sulphate; sedatives; tranquillizers; anti-depressants or topical anaesthetics such as xylocaine. |
