| 摘要 |
A scanning microscope for detecting and differentiating molecules 20 has a molecule 18 or group of molecules attached to the probe tip 12. The probe 12 interacts with the specimen 20 via the attached molecule 18 or molecules either by the tunneling current, as in a scanning tunneling microscope or by atomic forces as in an atomic force microscope. The molecular differences in either tunneling or atomic force with different molecules arise because of complementarity (or lack of it) of intermolecular bonds. In one embodiment, DNA sequences would be detected by probing with DNA monomers, looking for natural complementarity. <IMAGE> |
