发明名称 |
MUTANT PSEUDORABIES VIRUS, AND VACCINES CONTAINING THE SAME |
摘要 |
2065002 9102795 PCTABS00003 The invention relates to a pseudorabies virus (PRV) not found in nature and having a genome containing a mutation in the protein kinase gene region and/or in the 28K gene region. The mutation is e.g. a nucleic acid substitution, deletion, insertion or inversion, or a combination thereof. The mutations are introduced, by genetic engineering techniques, into the genome of a naturally occuring PRV, preferably NIA-3. Insertions may be nucleic acid sequences encoding antigenic polypeptides characteristic of a pathogen found in pigs. The invention also relates to vaccines containing a pseudorabies virus according to the invention, and to a process for preparing such vaccines.
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申请公布号 |
CA2065002(A1) |
申请公布日期 |
1991.02.18 |
申请号 |
CA19902065002 |
申请日期 |
1990.08.17 |
申请人 |
STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN |
发明人 |
DE WIND, NIELS;VAN ZIJL, MARIA M.;GIELKENS, ARNOLD L. J.;BERNS, ANTONIUS J. M. |
分类号 |
A61K39/245;A61K38/00;A61K39/00;C07K14/03;C12N7/00;C12N9/12;C12N15/00;C12N15/09;C12N15/869;(IPC1-7):C12N7/01;C12N15/38;C12N15/86 |
主分类号 |
A61K39/245 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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