发明名称 |
Formulation for lipophilic IL-2 proteins |
摘要 |
An improved process for recovering and purifying lipophilic recombinant proteins such as human beta -interferon and interleukin-2 from their hosts yields a protein preparation which may be formulated into a stable pharmaceutical composition having a therapeutically effective amount of the biologically active recombinant lipophilic protein dissolved in a non-toxic, inert, therapeutically compatible aqueous-based carrier medium at a pH of 6.8 to 7.8 which medium also contains a stabilizer for the protein, such as human serum albumin, normal serum albumin and human plasma protein fraction.
|
申请公布号 |
US4992271(A) |
申请公布日期 |
1991.02.12 |
申请号 |
US19850775751 |
申请日期 |
1985.09.13 |
申请人 |
CETUS CORPORATION |
发明人 |
HANISCH, WOLFGANG H.;FERNANDES, PETER M.;TAFORO, TERRANCE |
分类号 |
C12P21/02;A61K38/00;A61K38/21;A61K47/00;A61K47/36;A61K47/42;A61P43/00;C07K1/113;C07K14/55;C07K14/565 |
主分类号 |
C12P21/02 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|