| 摘要 |
Selegiline hydrochloride is a highly effective anti-Parkinsonic with low toxicity. The basis of this way of producing the salt is that 1-phenyl-2-methylaminopropane is allowed to react with a mixture of propargyl alcohol, triphenylphosphine and tetrachloromethane, in the presence of triethylamine, in an environment of dimethylformamide or acetonitrile, in a temperature range of 5 to 60 degrees C, and subsequently with hydrogen chloride in isopropyl alcohol.
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| 申请人 |
HAJICEK JOSEF ING. CSC.,CS;HRBATA JIRI PHARMDR. OLOMOUC,CS;PIHERA PAVEL,CS;BRUNOVA BOHUMILA ING. CSC.,CS;FERENC MILAN RNDR.,CS;KREPELKA JIRI ING. CSC.,CS;KVAPIL LUBOMIR RNDR.,CS;POSPISIL JOSEF,CS |
发明人 |
HAJICEK JOSEF ING. CSC.,CS;HRBATA JIRI PHARMDR. OLOMOUC,CS;PIHERA PAVEL,CS;BRUNOVA BOHUMILA ING. CSC.,CS;FERENC MILAN RNDR.,CS;KREPELKA JIRI ING. CSC.,CS;KVAPIL LUBOMIR RNDR.,CS;POSPISIL JOSEF,CS |
