发明名称 |
NYE 2-OXO-3,8-DIAZASPIRO(4,5)DECANDERIVATER, FARMASOEYTISKE PREPARATER SOM INNEHOLDER DEM OG FREMGANGSMAATE FOR FREMSTILLING AV DEM. |
摘要 |
4,4-disubstd piperidine derivs of formula (I) and their acid addn and quaternary ammonium salts are new. In (I) R1 = H or C0NHR; R = H, 1-12C alkyl, 3-6C cycloalkyl or a carboxyclic 6-10C aryl or carbocycline (6-10C aryl) 1-4C alkyl opt ring substd by one or more halo, 1-4C alkyl or 1-4C alkoxy; R2 = ethynyl or C0CH3; Ph1 and Ph2 = phenyl opt substd by one or more halo, 1-4C alkyl, 1-4C alkoxy, trihalo or 0H opt esterified by a 1-4C alkansic acid; n = 1-2. - 3 Cpds (I) ie 1-(3,3-bis(4-fluorophenyl)-2-propenyl)-4 ethynyl-4-hydroxypiperidine hydrochloride, (Ib) 1-(4,4-bis(4-fluorophenyl)-3- butenyl)-4-ethynyl-4-hydroxy piperidine hydrochloride (Ia) and 1-(4,4-bis(4-fluorophenyl)-3- butenyl)-4-benzylcarbamoyloxy-4 ethynylpiperidine are specifically claimed. |
申请公布号 |
NO903511(A) |
申请公布日期 |
1991.02.11 |
申请号 |
NO19900003511 |
申请日期 |
1990.08.09 |
申请人 |
RICHTER GEDEON VEGYESZETI GYAR RT. |
发明人 |
TOTH, EDIT;TOERLEY, JOZSEF;GOEROEG, SANDOR;SZPORNY, LASZLO;KISS, BELA;PALOSI, EVA;GROO, DORA;LASZLOVSZKY, ISTVAN;LAPIS, ERZSEBET;AUTH, FERENC;GAAL, LASZLO |
分类号 |
A61K31/42;A61K31/445;A61P25/18;A61P25/20;A61P25/24;A61P25/26;A61P25/28;C07D211/22;C07D491/10;C07D491/113;C07D498/10 |
主分类号 |
A61K31/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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