PEPTIDE INHIBITORS OF HUMAN PAPILLOMA VIRUS PROTEIN BINDING TO RETINOBLASTOMA GENE PROTEINS

摘要

41/RJN 17995IA TITLE OF THE INVENTION PEPTIDE INHIBITORS OF HUMAN PAPILLOMA VIRUS PROTEIN BINDING TO RETINOBLASTOMA GENE PROTEINS The present invention comprises biochemically pure polypeptides, identified from the human Papilloma virus (HPV) E7 protein, which efficiently block the binding of the HPV E7 protein to the protein encoded by the retinoblastoma gene (RBG). The polypeptides are antagonists of the biochemical interaction of the HPV E7 protein and the RBG protein. The invention is useful in the treatment of genital warts and cervical cancer. One polypeptide of the present invention (Peptide A) has an amino acid sequence of: Thr-Asp-Leu-Tyr-Cys-Tyr-Glu-Gln-Leu-Asn-Asp-Ser-Ser.