发明名称 |
TUMOUR NECROSIS FACTOR BINDING LIGANDS |
摘要 |
The present invention relates to ligands which bind to human tumour necrosis factor alpha (TNF) in a manner such that upon binding of these ligands to TNF the biological activity of TNF is modified. In preferred forms the ligand binds to TNF in a manner such that the induction of endothelial procoagulant activity of the T NF is inhibited; the binding of TNF to receptors on endothelial cells is inhibited; the induction of fibrin deposition in the tumour and tumour regression activities of the TNF are enhanced; and the cytotoxicity and receptor binding activities of the TNF ar e unaffected or enhanced on tumour cells. The ligand is preferably an antibody, F(ab) fragment, single domain antibody (dABs) single chain antibody or a serum binding protein. It is preferred, however, that the ligand is a monoclonal antibody or F(ab) fragme nt thereof.
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申请公布号 |
CA2064915(A1) |
申请公布日期 |
1991.02.08 |
申请号 |
CA19902064915 |
申请日期 |
1990.08.07 |
申请人 |
PEPTIDE TECHNOLOGY LTD. |
发明人 |
RATHJEN, DEBORAH A.;ROGER, ASTON |
分类号 |
A61K38/00;A61K45/00;A61K47/48;A61P35/00;A61P35/02;C07K14/435;C07K14/47;C07K14/52;C07K14/525;C07K16/00;C07K16/18;C07K16/24;C07K19/00;C12N5/10;C12N5/20;C12N15/02;C12N15/06;C12N15/09;C12P21/08;C12R1/91;(IPC1-7):C12P21/08 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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