| 摘要 |
<p>A therapeutic composition comprising a combination of a 3'-fluoro-2',3'-dideoxy-nucleoside compound (I) of formula (I), wherein B is adenine, thymine, guanine, cytosine, inosine, uracil, 5-ethyluracil, 2,6-diaminopurine; and a 2',3'-dideoxynucleoside compound (II) of formula (II), wherein X is N3 or H or together with Y an additional carbon-carbon bond, Y and Z are independently H, OH or F, and B is adenine, thymine, guanine, cytosine, inosine, uracil, 5-ethyluracil, 2,6-diaminopurine, in a ratio giving a synergistic antiviral effect. The composition can be used in the treatment or prophylaxis of infections caused by viruses using reverse transcriptase for replication, especially HIV infections and AIDS.</p> |
