摘要 |
<p>The invention relates to nitrogen- and sulfur-containing heterocyclic compounds of the formula (I), <CHEM> wherein Ar represents an optionally mono- or polysubstituted aryl or heteroaryl group; R<1> represents a carbonyl or (C2-6alkenyl)-carbonyl group; R<2> represents a hydrogen atom, or a C1-6alkyl, phenyl or phenyl(C1-4alkyl) group; R<3> represents a hydrogen atom or a (C1-6 alkoxy)carbonyl group; R<4> and R<5>, which may be the same or different, represent a hydrogen atom or a C1-6alkyl group; R<6> represents a hydrogen atom or a C1-6alkyl group or halophenyl group; m is 0 or 1; and n is 1 or 2, with the proviso that R<2> is a hydrogen atom when m is 0, and acid addition salts of the compounds of formula (I) and pharmaceutical compositions thereof. The invention also relates to processes for the preparation of these compounds. The compounds of formula (I) show a significant cerebral antihypoxic activity.</p> |
申请人 |
RICHTER GEDEON VEGYESZETI GYAR R.T. |
发明人 |
NADOR, KAROLY, DR.;SCHEIBER, PAL, DR.;SZELECSENYI, ERZSEBET, DR.;MOLNAR, BELA;SZPORNY, LASZLO, DR.;KISS, BELA;KARPATI, EGON, DR.;PALOSI, EVA, DR.;GROO, DORA, DR.;LASZLOVSZKY, ISTVAN, DR.;SZOMBATHELYI, ZSOLT, DR.;SARKADI, ADAM, DR.;GERE,ANIKO;BODO,MIHALY,DR.;CSOMOR,KATALIN;LASZY,JUDIT,DR.;SZENTIRMAY,ZSOLT |