A vaccine composition for animals susceptible to infection by canine distemper virus. The vaccine comprises a small but immunologically effective amount of an inactivated canine distemper virus in combination with a non-toxic pharmaceutically acceptable immunologic adjuvant. A preferred method of inactivation of canine distemper virus by either exposure of the virus to an inactivating effective amount of binary ethyleneimine or alternatively exposure of the virus to long wavelength ultraviolet light in the presence of a furocoumarin.
申请公布号
US4990367(A)
申请公布日期
1991.02.05
申请号
US19900463763
申请日期
1990.01.12
申请人
DIAMOND SCIENTIFIC COMPANY
发明人
BASS, EDMUND P.;KELSEY, WILLIAM H.;MCFARLAND, MICHAEL D.