| 摘要 |
PURPOSE:To obtain a lipid metabolic improver, containing microbial dell lipids of a marine microorganism having the ability to produce eicosapentaenoic acid and/or the aforementioned microbial cells as an active ingredient and capable of effectively reducing lipids in blood and the liver and fatty tissue weight of animals. CONSTITUTION:A lipid metabolic improver obtained by culturing a marine microorganism, e.g. a microorganism belonging to the genus Pseudomonas, Alteromonas, Shewanella, Deleya, Alteromarinus, Pateurella or Vibrio, having the ability to produce eicosapentaenoic acid in a culture medium according to a conventional method, collecting the resultant microbial cells by a centrifugal separation method, etc., drying the collected microbial cells to provide microbial powder, extracting the obtained powder with an organic solvent, desolvating the powder, fractionating the resultant powder with acetone and affording an eicosapentaenoic acid-bound phospholipid as a substance insoluble in acetone. The aforementioned phospholipid composition contains phosphatidylethanolamine and phosphatidylglycerol as principal ingredients and the constituent fatty acids thereof are eicosapentaenoic, oleic, palmitic acids, etc. |
