7-THIAZOLYLACETAMIDO-3-PROPENYLCEPHEM DERIVATIVE

摘要

NEW MATERIAL:A compound shown by formula I {R1 is (fluorine-substituted) lower alkyl; A is group shown by formula II [R is (hydroxy-substituted) lower alkyl; R3 is lower alkyl substituted with group selected from carbamoyl and OH], formula III or formula IV (R4 is hydroxy-substituted lower alkyl)}. EXAMPLE:7beta-[2-(2-Amino-1,3-thiazol-4-yl)-(Z)-2- methoxyiminoacetamido]-3-[(E)-3-(carbamoylmethylethylmethylammonio)-1- propenyl]-3--cephem-4-carboxylate shown by formula V. USE:An antimicrobial agent against Gram-positive and Gram-negative bacteria. PREPARATION:A compound shown by formula VI (X is halogen) or a compound (salt) prepared by protecting the amino group or the carboxyl group with a protecting group in reacted with a compound shown by formula A' (A' is amino corresponding to A) or salt thereof.