发明名称 |
CHIMERIC ANTIBODIES DIRECTED AGAINST A HUMAN GLYCOPROTEIN ANTIGEN |
摘要 |
The present invention discloses novel chimeric monoclonal antibodies, directed against proteoglycans of human melanoma cells, having antigen-specific variable regions of defined amino acid sequences. DNA constructs for the light and heavy chain variable regions comprising the novel antibodies of the invention are provided. Eukaryotic host cells capable of expression of the chimeric antibodies and comprising the novel chimeric antibody-encoding DNA constructs are also provided. |
申请公布号 |
AU5999490(A) |
申请公布日期 |
1991.01.31 |
申请号 |
AU19900059994 |
申请日期 |
1990.07.30 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
LISA SELSAM BEAVERS;THOMAS FRANK BUMOL;ROBERT ALAN GADSKI |
分类号 |
G01N33/574;A61K38/00;A61K39/395;A61P35/00;C07K14/00;C07K16/00;C07K16/30;C07K16/46;C12N15/13;C12P21/08;C12R1/91 |
主分类号 |
G01N33/574 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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