| 摘要 |
<p>(A) Chloramphenicol silyl ethers (II) R1 = - R4 R3 and R4 = C1-6 alkyl, phenyl-, benzyl- R5 = C1-6 alkyl-, phenyl-, benzyl-, H- R2 = H- or (B) Therapeutic preparations containing (II) Antibacterial; overcomes bitter taste of chloramphenicol; prolongs blood level. Silylation at room temperature of chloramphenicol (I) with e.g. hexamethyldisilazane using trimethylchlorosilane as catalyst. This causes silylation of both R1 and R2. Hydrolysis to the mono(trimethyl silyl) ether is obtained by mild acid conditions using 0.4% acetic acid in methanol.</p> |
