| 摘要 |
Diazepinones of the general formula I …<IMAGE>… in which… A is the 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one group bonded in the 11 position, the 5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one group bonded in the 5 position, the 5,11-dihydro-10H-pyrido[3,2-b][1,4]benzodiazepin-10-one group bonded in the 5 position or the 4,9-dihydro-10H-thieno[3,4-b][1,5]benzodiazepin-10-one group bonded in the 4 position, each of which can be substituted in position 1 and/or 3 by alkyl radicals with 1 to 4 carbon atoms or in position 3 by chlorine, fluorine or bromine, the 6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one group bonded in the 11 position or the 1-methyl-1,4,9,10-tetrahydropyrrolo[3,2-b][1,5]benzodiazepin-10-one group bonded in the 4 position, each of which can be substituted in position 3 by methyl or chlorine,… R1 is a hydrogen atom or an alkyl group with 1 to 3 carbon atoms,… R2 is an alkyl group with 1 to 3 carbon atoms and… n and m are, independently of one another, the integers 1 to 3, where appropriate their isomers and enantiomers and their physiologically tolerated acid addition salts can be used as agents for the therapy of microcirculatory disorders, but especially for the therapy of states of shock, such as haemorrhagic shock. |
