A new technique for rapid peptide coupling.

摘要

The present invention is directed to a process for forming a peptide bond between a first AMINO ACID containing a free N-terminal amino group and an acylating N-terminal amino protected second AMINO ACID which comprises reacting under amide forming conditions said first AMINO ACID with said second AMINO ACID in the presence of a basic and catalytic effective amount of a mixture comprising a tertiary amine of the formula: <CHEM> and a N-hydroxy nitrogen containing heterocycle or the quaternary ammonium salt of said mixture, wherein R1, R2, and R3 are independently lower alkyl, or R1 and R2 together with the nitrogen to which they are attached form a heterocyclic ring.