| 发明名称 |
HETEROARYL-3-OXO-PROPANENITRILE DERIVATIVES USEFUL IN THE TREATMENT OF RHEUMATOID ARTHRITIS AND OTHER AUTOIMMUNE DISEASES |
| 摘要 |
This invention relates to a method of treating rheumatoid arthritis, which method comprises administering to a mammal a therapeutically effective amount of a compound of formula (I): <IMAGE> (I) wherein R1 is unsubstituted or substituted phenyl; R2 is a morpholinomethyl group; R3 is hydrogen; R4 is hydrogen or C1-C6 alkyl; Ra is hydrogen; and Rb is a group -(A)m-R5 wherein m is zero or 1, A is a C1-C6 alkylene chain and R5 is unsubstituted or substituted phenyl; or a pharmaceutically acceptable salt thereof. |
| 申请公布号 |
ZA9002649(B) |
申请公布日期 |
1991.01.30 |
| 申请号 |
ZA19900002649 |
申请日期 |
1990.04.05 |
| 申请人 |
FARMITALIA CARLO ERBA S.R.L. |
发明人 |
GIANFEDERICO DORIA;ANNA MARIA ISETTA;RINALDO FERRECCIO;MARIO FERRARI;MARIA CHIARA FOMASIERO;DOMENICO TRIZIO |
| 分类号 |
C07D231/54;A61K31/34;A61K31/38;A61K31/40;A61K31/415;A61K31/44;A61P37/00;C07D491/048;C07D495/04 |
主分类号 |
C07D231/54 |
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