发明名称 |
4-(4-(4-(4-(2-(2,4-DIFLUOROPHENYL)-2-(1H-AZOLYL-METHYL)-1,3-DIOXOLAN-4-YL)METHOXY)PHENYL)-1-PIPERAZINYL)PHENYL)TRIAZOLONES |
摘要 |
Novel 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4 -yl] methoxy]phenyl]-1-piperazinyl]phenyl]triazolones of formula <CHEM> wherein Q is N or CH; R is hydrogen, C1-6alkyl or arylC1-6alkyl; and R<1> is hydrogen, C1-6alkyl or arylC1-6alkyl; wherein aryl is phenyl optionally substituted with up to 3 substituents each independently selected from halo, C1-6alkyl, C1-6alkyloxy and trifluoromethyl, the pharmaceutically acceptable acid addition salts and possible stereochemically isomeric forms thereof, which compounds are anti-microbial agents; pharmaceutical compositions containing such compounds as an active ingredient and methods of preparing said compounds and pharmaceutical compositions. |
申请公布号 |
PH25023(A) |
申请公布日期 |
1991.01.28 |
申请号 |
PH19900000366 |
申请日期 |
1988.03.25 |
申请人 |
JANSSEN PHARMACEUTICA N.V. |
发明人 |
JAN HEERES;LOUIS J.E. VAN DER VEKEN;LEO J.J. BACKX |
分类号 |
C07D249/08;A61K31/495;A61P31/04;C07D233/56;C07D233/60;C07D249/12;C07D253/04;C07D295/00;C07D317/00;C07D405/12;C07D405/14;C07D521/00 |
主分类号 |
C07D249/08 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|