| 摘要 |
2063799 9101374 PCTABS00003 Described is a method of preventing undesired initiation of translation at an internal initiator codon in a DNA sequence encoding a polypeptide, wherein a Shine-Dalgarno sequence is located upstream from the internal initiator codon. The method includes altering either the internal initiator codon or the Shine-Dalgarno sequence, or both, such that inappropriate initiation of translation and/or ribosome binding is prevented.
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