| 摘要 |
Compounds of the formula <CHEM> wherein A together with the two carbon atoms denoted as alpha and beta signifies a group of the formula <CHEM> and the dotted line signifies the double bond present in cases (i) and (iii); and wherein n stands for zero, 1, 2 or 3, one of R<1> and R<2> signifies carboxy or alkoxycarbonyl and the other signifies hydrogen, R<3> signifies hydrogen, alkyl, alkoxy, aryloxy, azido, cyano or alkylthio, R<4>, R<5>, R<6> and R<7> each signify hydrogen or alkyl or, when R<1> signifies carboxy or alkoxycarbonyl and n stands for 1, R<4> and R<6> together can signify a carbon-carbon bond or, when R<2> signifies carboxy or alkoxycarbonyl, R<5> and R<7> together can signify a carbon-carbon bond, R<8> signifies halogen, alkyl, haloalkyl or alkoxy and R<9> signifies hydrogen, halogen, alkyl or alkoxy, and pharmaceutically acceptable salts of the compounds of formula I in which one of R<1> and R<2> signifies carboxy and the other signifies hydrogen with bases, can be used as medicaments for the treatment of rheumatoid arthritis, inflammatory respiratory diseases, inflammatory bowel disease, shock and inflammation associated with ischemia. They can be manufactured according to generally known methods. |
