| 摘要 |
<p>NEW MATERIAL:A compound expressed by formula I (R<1> is OH-substituted lower alkyl; R<2> and R<3> are OH; R<4> is H or OH; R<5> is H, halogen, OH or lower alkoxy; R<6> is H, lower alkyl, carboxy-substituted lower alkyl, lower alkoxy- substituted aralkyl, etc.). EXAMPLE:(5R,6R,7S,8R,8aS)-Hexahydro-6,7,8-trihydroxy-5-hydroxymethyl-5 a,6,7,8- di-O-isopropylideneimidazo[1,2-a]pyridine-2,3-dione expressed by formula II. USE:A medicine and immunological modulating substance especially useful as the immunological modulating substance against immunosuppressive factors of leukocytic systems. PREPARATION:For example, 5-deoxy-2,3;4,6-O-protecting group-substituted-5- oxamylamino-D-mannoses are produced from D-mannosamines expressed by formula III and then condensed and cyclized to afford the compound expressed by formula I, such as a compound expressed by formula II.</p> |
