| 摘要 |
The invention relates to a solid pharmaceutical dosage form from which the active substance or the mixture of active substances can dissolve immediately or continuously, quantitatively after release, specifically after a defined time, i.e. after a defined time interval has elapsed, approximately pH-independently, i.e. independent of the hydrogen ion and hydroxyl ion concentrations and/or other ions and independently of enzymes in the surrounding fluid, characterised in that the dosage form containing an active substance or a mixture of active substances, a non-colloidal auxiliary (disintegrant) which can swell in water, and at least one vehicle which dissolves in water (osmosis-inducing substance) and optionally other auxiliaries is coated with a semipermeable membrane which springs open like a lid after a defined time on penetration of aqueous fluid owing to the swelling pressure (disintegration) of the swellable non-colloidal auxiliary and owing to the simultaneously occurring osmotic pressure and, where appropriate, internally generated gas pressure, and quantitatively releases the active substance or mixture of active substances. A process for producing, and the use of, the solid pharmaceutical dosage form are also described.
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