发明名称 |
DERIVATIVES OF PLATINUM (P) WITH METHYL SILICONE, METHOD OF OBTAINING THEM AND ANTITUMORAL MEANS BASED THEREON. |
摘要 |
<p>Derivatives of platinum (P) with methyl silicone are xerogels - a product of reaction between a complex compound of platinum (P) in an aqueous solution of sodium chloride, on the one hand, and a hydrogel of methyl silicone, on the other hand, at a molar ratio of Pt:Si:NaCl equal to 1-3:50:23-69, said product being a three-dimensional cross-linked polymer of globular structure with a globule diameter of 4.0-7.0 nm and a specific surface of 80-200 m<2>/g and having a link of the following general formula: -{[PtCl(NH3)2O0,5]n(NaCl)5n(CH3SiO1,5)50(Na2O)10(H2O)20}-, where n = 1 to 3. A method of obtaining said compounds consists in reacting the complex compound of platinum (P) in the aqueous solution of sodium chloride with the hydrogel of methyl silicone at a molar ratio of Pt:Si:NaCl equal to 1-3:50:23-69 with subsequent extraction of the desired product. The claimed compounds have antitumoral activity. The claimed means of antitumoral action consists of an active agent - the claimed compound having a link of the following formula: -{[PtCl(NH3)2O0,5]2(NaCl)10(CH3SiO1,5)50(Na2O)10(H2O)20}-.</p> |
申请公布号 |
EP0407623(A1) |
申请公布日期 |
1991.01.16 |
申请号 |
EP19900902712 |
申请日期 |
1990.01.30 |
申请人 |
INSTITUT FIZICHESKOI KHIMII IMENI L.V.PISARZHEVSKOGO AKADEMII NAUK UKRAINSKOI SSR;KIEVSKY GOSUDARSTVENNY INSTITUT USOVERSHENSTVOVANIA VRACHEI |
发明人 |
VOLCHENSKOVA, ILIMA ILIODOROVNA;MAIDANEVICH, NADEZHDA NIKOLAEVNA;BUDARIN, LEV IVANOVICH;SAMODUMOVA, INNA MIKHAILOVNA;GIRIN, VITALY NIKOLAEVICH;SHALIMOV, SERGEI ALEXANDROVICH;TROKHIMENKO, ELENA PETROVNA;KEISEVICH, LJUDVIG VLADISLAVOVICH |
分类号 |
A61K31/695;A61K33/24;A61P35/00;C07F15/00;C08G77/398 |
主分类号 |
A61K31/695 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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