发明名称 |
METHOD OF 9-/-HYDROXYETHOXYMETHYL/GUANINE PRODUCTION |
摘要 |
There is disclosed a process for preparing 9-(2-hydroxyethoxymethyl)-guanine (acyclovir) of the formula IV <IMAGE> IV wherein a novel compound of the formula I <IMAGE> I wherein R and R' may be the same or different and represent hydrogen, (C1-C8)acyl or benzyl and R1 represents (C1-C8)acyl, is hydrolyzed under mild basic conditions. Also disclosed is the novel compound of the formula I, a process for the preparation thereof by condensing a novel compound of the formula II <IMAGE> II with a compound A-CH2-O-CH2CH2-OR' (A is a leaving group, Q is hydrogen or a leaving group), the novel compound of the formula II and a process for the preparation thereof by means of condensing glyoxal hydrate and a compound of the formula V <IMAGE> V |
申请公布号 |
CS272215(B2) |
申请公布日期 |
1991.01.15 |
申请号 |
CS19850009666 |
申请日期 |
1985.12.20 |
申请人 |
KRKA TOVARNA ZDRAVIL N.SOL.O.,YU |
发明人 |
KOBE JOZE DR. ING.,YU;GNIDOVEC JOZE ING.,YU;ZUPET PAVLE DR. ING.,YU |
分类号 |
C07D473/18;C07D473/00;C07D487/04;C07D487/14 |
主分类号 |
C07D473/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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