| 摘要 |
<p>NEW MATERIAL:The optically active compound of formula I [R<1> is 1-12C group selected from (alkoxy)alkyl, cycloalkyl and aralkyl having hetero atom on aromatic ring or alkyl; R<2> is H or easily eliminable protecting group selected from acyl, silyl, aralkyl and alkyloxyalkyl; * represents asymmetric carbon atom]. EXAMPLE:The compound of formula II. USE:Useful as a production raw material for optically active gamma-lactone derivative which is a key intermediate for the synthesis of prostaglandin. PREPARATION:The objective compound of formula I can be produced by oxidizing an optically active compound of formula III with an oxidizing agent such as CrO3-pyridine. The starting compound of formula III can be synthesized by reacting a halogen compound of formula IV with a strong base, converting the resultant compound of formula V to a compound of formula VI with a strong base and reacting the compound with a compound of formula VII.</p> |
