| 摘要 |
PURPOSE:To easily obtain the subject compound under neutral condition by cyanization of an acetal with a silyl cyanide compound in the presence of a catalytic amount of transition metal compound using a solvent acting as a Lewis base. CONSTITUTION:The objective alkoxynitrile compound of formula V (R<10> is H, cyano, alkyl, alkoxy or aryl) can be obtained by reaction between (A) an acetal, ketal or orthoester of formula III (R<1> is alkyl: R<2> is 1-alkenyl or aryl; R<3> is H, alkyl, alkoxyl or aryl) and (B) a silylcyanide compound of formula IV (R<4>-R<6> are each alkyl or aryl) in the presence of (C) a transition metal compound of formula MXn [M is transition metal; X is halogen, of formula I or II (R<6>-R<9> are each H, alkyl or aryl); (n) is 1-3] (e.g. NiCl2, CoCl2, PdCl2). In this process, the reaction will proceed under neutral condition, and a solvent such as THF, ether or DMF can be used without any restriction. |
