| 摘要 |
The invention provides a series of novel heterocyclic ketones of formula I <CHEM> and pharmaceutically acceptable base-addition salts thereof, in which the values of R<4>, L, A, X and Q have the meanings defined in the following specification. The compounds of formula I are inhibitors of human leukocytic elastase. The invention also provides pharmaceutical compositions containing a compound of formula I, or a pharmaceutically acceptable base-addition salt thereof, and processes and intermediates for the manufacture of compounds of formula I. |
