New 1-cinnamyl-4-(1-phenyl)-cyclo:hexyl)-piperazine - used to inhibit formation of cardiovascular atheroma

摘要

Cpds. of formula (I) are new. R = 1-phenyl cyclohexyl (a) or 4-cyano-4(3,4,5-trimethoxyphenyl)-5-methyl hexyl (b). I(a) is prepd. by reacting cinnamyl piperazine (IV) with cyclohexanone (V) in an aq. soln. The reaction takes place in the presence of sodium hydrogen sulphite, which is reacted with (V) to form an adduct before adding (IV) and KCN. The resulting 1-cinnamyl-4-(1-cyano)cyclohexyl-piperazine is refluxed with phenyl magnesium bromide and treated with ammonium chloride. USE/ADVANTAGE - To inhibit the formation of atheroma in blood vessels. (I) can be used after angioplasty and heart bypass operations.