发明名称 |
PURIFIED, HIGHLY SPECIFIC ANTIBODIES AGAINST GENE PRODUCTS INCLUDING RETINOBLASTOMA AND METHOD |
摘要 |
A method of identifying epitopes to gene products, specifically the human retinoblastoma (Rb) gene and the corresponding antigenic polypeptides. The amino acid sequence has a combination of low solubility and high hydrophilicity. Highly specific high-affinity anti-Rb-IgGs have been purified using the techniques of this invention. The anti-Rb-IgGs have been used to immuno-precipitate and produce Western Blot patterns associated with normal and abnormal Rb proteins. The method and products of this invention can be used in various diagnostic procedures. |
申请公布号 |
WO9012807(A3) |
申请公布日期 |
1991.01.10 |
申请号 |
WO1990US02017 |
申请日期 |
1990.04.13 |
申请人 |
BAYLOR COLLEGE OF MEDICINE |
发明人 |
XU, HONG-JI;BENEDICT, WILLIAM, F.;HU, SHI-XUE |
分类号 |
A61K39/00;A61K39/395;C07K7/00;C07K7/06;C07K7/08;C07K14/00;C07K14/47;C07K16/00;C07K16/32;C07K17/00;C07K17/02;C07K19/00;C12P21/08;G01N33/53;G01N33/531;G01N33/574;(IPC1-7):C07K7/08;C07K7/10 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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