发明名称 |
Process for removing bacterial endotoxin from gram-negative polysaccharides. |
摘要 |
<p>A process for removing endotoxin from Gram-negative polysaccharides such as polyribosylribitol phosphate by solubilizing polysaccharide-containing powder derived from Gram-negative bacteria fermentation broth to provide a divalent counter ion for endotoxin and adding alcohol incrementally to induce lipolysaccharide precipition, and mixing material resulting from the alcohol addition with a nonionic resin, a detergent and a chelating agent. A process for removing endotoxin from Gram-negative polysaccharides such as H. influenzae polyribosylribitol phosphate by mixing with a nonionic resin, a detergent and a chelating agent. A process for removing endotoxin from Gram-negative polysaccharides such as H. influenzae polyribosylribitol phosphate by adding alcohol incrementally until substantially all lipopolysaccharide precipitates.</p> |
申请公布号 |
EP0407037(A1) |
申请公布日期 |
1991.01.09 |
申请号 |
EP19900306237 |
申请日期 |
1990.06.08 |
申请人 |
MERCK & CO. INC. |
发明人 |
RIENSTRA, MARK S.;SCATTERGOOD, EDGAR M.;SITRIN, ROBERT D. |
分类号 |
C08B37/00;A61K39/102;C12P19/04;C12R1/21;(IPC1-7):A61K39/02 |
主分类号 |
C08B37/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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