发明名称 |
BIS-INDOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME |
摘要 |
The invention relates to novel bis-indole derivatives of the general formula. (I) (I) wherein R1 stands for a hydrogen atom or an acetyl group; R2 stands for a hydrogen atom; R3 means an ethyl group of .alpha.-position; or R2 and R3 together represent an oxygen bridge; R4 represents an ethyl or hydroxyl group of .beta.-position; and R5 stands for a hydrogen atom or a hydroxyl group; A represents a straight-chain C1-10 alkyl; a branched-chain C3-10 alkyl group; a C1-4 alkyl group containing in the omega position a hydroxyl, C2-5 alkanyloxy, carbamoyl or formylamino substituent; a benzyl group, a pyridyl group or a phenyl group; and X stands for a sulphur atom, or pharmaceutically acceptable acid addition salts and pharmaceutical preparations containing these compounds. Further on, the invention relates to a process for preparing these compounds and preparations. The compounds of the general formula (I) show a cytostatic activity with less toxicity than that of the known vinblastine-type bis-indole alkaloid drugs which are commercially available. |
申请公布号 |
CA1278790(C) |
申请公布日期 |
1991.01.08 |
申请号 |
CA19860511394 |
申请日期 |
1986.06.12 |
申请人 |
RICHTER GEDEON VEGYESZETI GYAR R.T. |
发明人 |
SZANTAY, CSABA;SZABO, LAJOS;HONTY, KATALIN;KEVE, TIBOR;ACS, TIBOR;ECKHARDT, SANDOR;SUGAR, JANOS;SOMFAI, ZSUZSA;IVAN, EVA;KNEFFEL, ZSUZSA |
分类号 |
A61K31/475;A61P35/00;C07D519/04 |
主分类号 |
A61K31/475 |
代理机构 |
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地址 |
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