FURFURYL DERIVATIVES OF VINBLASTINE-TYPE BISINDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME

摘要

FURFURYL DERIVATIVES OF VINBLASTINE-TYPE OF BIS INDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME The invention relates to novel furfuryl derivatives of the general formula (I), (I) ( I ) wherein R1 stands for a hydrogen atom or an acetyl group, R2 stands for a hydroxyl or ethyl group of .beta.-position R3 means an ethyl group of .alpha.-position; R4 represents a hydrogen atom; or R3 and R4 together represent an oxygen bridge; and B stands for a hydroxyl or an o-acetyl group, as well as their acid addition salts and pharmaceutical preparations containing these compounds. The invention also relates to a process for preparing these compounds and preparations. The compounds of the general formula (I) show a cytostatic activity with less toxicity than that of the commercially available known vinblastine-type bis-indole alkaloid drugs.