| 摘要 |
NEW MATERIAL:A compound of formula I [R1-R6 are each H, halogen, OH, lower alkyl, lower alkoxy, amino, etc.; R7 and R8 are either each lower alkyl or form 1-4C alkylene through mutual linkage; A and A' are each single bond, -O-, -NH-, -NHCO-, SO2NH-, etc., (- is bond to either to Y or Y'); Y and Y' are each lower alkylene or lower alkenylene] or its acid-added salt. EXAMPLE:N,N'-bis-[4-(3,4,5-trimethoxyphenyl)buthyl]homopiperazine dihydrochloride. USE:Medicines. An active ingredient for brain protectives. Having excellent brain protective effect, low toxic, highly safe and giving great efficacy through oral administration, thus useful for the improvement or promotion inhibition of e.g. brain dysfunction involved in cerebral hemorrhage, subarachnoid hemorrhage, etc. PREPARATION:For example, a compound of formula II (X is halogen, methyloxy, etc.) is reacted with a second compound of formula III to obtain the objective compound of the formula I where Y'=Y and A'=A. |
