Substd. 3-benzyl-3,4-di:hydro-4-oxo-1-phthalazine:acetic acid prepn. - by reacting 3,4-di:hydro-4-oxo-1-phthalazine:acetic acid with 4-bromo-2-fluoro-benzyl bromide in appropriate solvents

摘要

Prepn. of 3-((4-bromo-2-fluorophenyl)methyl) -3,4-dihydro-4-oxo-1- phthalazineacetic acid (I) is new, and comprises reacting (II) with (III). The reaction is carried out in a protic polar solvent (IV), an aprotic polar solvent (V) or a mixt. of (IV) and (V) with an opt. phenyl substd. tetraalkyl ammonium hydroxide (VI). Pref. (IV) = a lower alkanol, pref. 2-propanol; (V) = N,N-dimethylformamide (DMF), acetonitrile, dimethylsulphoxide, N,N-dimethylacetamide or N-methylpyrrolidine, pref. DMF. (VI) = tetramethyl-, tetraethyl-, tetrabutyl-, benzyltrimethyl-, cetyltrimethyl- or tricaprylmethyl- ammonium hydroxide, pref. tetramethylammonium hydroxide.