发明名称 |
Aqueous steroid formulations for nasal administration |
摘要 |
A non-stinging aqueous anti-inflammatory steroid formulation suitable for intranasal administration comprises: an anti-inflammatory steroid in an amount between about 0.01% and about 0.05% (w/v); propylene glycol in an amount between about 2% and about 10% (w/v); PEG 400 in an amount between about 10% and about 25% (w/v); polysorbate 20 in an amount between about 1% and about 4% (w/v); an effective amount of a preservative; an effective amount of a stabilizer; an effective amount of an antioxidant; water; and pH buffering agent sufficient to adjust the pH of the resulting solution to between about 3.5 and about 7.
|
申请公布号 |
US4983595(A) |
申请公布日期 |
1991.01.08 |
申请号 |
US19880247008 |
申请日期 |
1988.09.20 |
申请人 |
SYNTEX (U.S.A.) INC. |
发明人 |
BENJAMIN, ERIC;ANIK, SHABBIR;LIN, YA-YUN T. |
分类号 |
A61K9/00;A61K31/57;A61K31/58 |
主分类号 |
A61K9/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|