发明名称 |
Percutaneous penetration enhancer of oleic acid and 2-ethyl-1,3-hexanediol |
摘要 |
Pharmaceutical preparations comprised of a pharmaceutically active ingredient and a carrier which comprises a percutaneous penetration enhancer comprised of 2-ethyl-1, 3-hexanediol alone or in combination with oleic acid is disclosed. The 2-ethyl-1, 3-hexanediol may be present in an amount in the range of about 50% to 100% based on the weight of the carrier. The oleic acid may be used in combination with 2-ethyl-1, 3-hexanediol in an amount of about 1 to 40% based on the weight of the carrier to provide a synergistic effect with respect to percutaneous penetration enhancement. The compound 2-ethyl-1, 3-hexanediol as used alone and/or in combination with the oleic acid has been found to significantly enhance the delivery of a drug, to a patient, from a transdermal delivery system.
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申请公布号 |
US4983396(A) |
申请公布日期 |
1991.01.08 |
申请号 |
US19890412730 |
申请日期 |
1989.09.26 |
申请人 |
KEY PHARMACEUTICALS, INC. |
发明人 |
BODOR, NICHOLAS;LOFTSSON, THORSTEINN |
分类号 |
A61K9/70;A61K31/21;A61K31/565;A61K47/10;A61K47/12 |
主分类号 |
A61K9/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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