| 摘要 |
4-17653/+ Novel pyrimidine derivatives Compounds of the formula (I) their tautomers and salts, in which Z is 0, S or N(R) and R is hydrogen or an aliphatic hydrocarbon radical; R1 is an unsubstituted or substituted aliphatic hydrocarbon radical, a cycloaliphatic or araliphatic hydrocarbon radical or an aromatic radical; R2 and R3, independently of one another, are halogen, acyl, an aromatic radical, unsubstituted or substituted amino, or carboxyl which, if desired, may be esterified or amidated; or R2 is -Zl-R'2 and R3 is -Z2-R'3, Z1 and Z2 independently of one another being a bond, O or S(O)n and n being 0, 1 or 2, and R'2 and R'3 independently of one another being hydrogen, an araliphatic or aliphatic hydrocarbon radical, the latter being unsubstituted or substituted and, if desired, interrupted by -O- or -S(O)n-, n being 0, 1 or 2; or R2 and R3 together are propylene or butylene or are the partial structure of the formula -CH=CH-CH=CH-, in which, if desired, one or two of the methyne groups are replaced by -N=; R4 is a group of the formula (Ia) in which Alk is a divalent aliphatic hydrocarbon; R5 is COOH, SO3H, haloalkanesulfamoyl, PO2H2, PO3H2 or 5-tetrazolyl; the rings A and B or the (hetero)aromatic ring jointly formed by R2 and R3 are, independently of one another, unsubstituted or substituted, can be used, for example, as phannaceutical activeingredients.
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