发明名称 RECEPTORS FOR FIBROBLAST GROWTH FACTORS
摘要 A fibroblast growth factor (FGF) receptor including a basic fibroblast growt h factor receptor has been purified. Various forms have been identified including soluble forms lacking any transmembrane segment. DNA sequences encoding full-length fibroblast growth factor receptors and polypeptides comprising a portion of an FGF-R ligand-binding domain have been isolated and sequenced. These DNAs include DNAs encoding for a basic FGF-R and a huma n FGF-R and are operably linked to control sequences and expressed in a culture of a compatible host transformed, transfected or electroporated by a cloning vehicle con- taining the DNA sequence. The invention also comprises antibodies to the receptor, methods of synthesizing the growth factor re- ceptor proteins, methods for providing analogs of the fibroblast growth fact or receptors. Methods for evaluating compositions which promote or inhibit fibroblastic growth factors and compositions which are agonistic or antagonistic to fibroblast growth factor receptors are also provided. Diagnostic and therapeutic uses are described.
申请公布号 CA2063431(A1) 申请公布日期 1991.01.07
申请号 CA19902063431 申请日期 1990.07.06
申请人 REGENTS OF THE UNIVERSITY OF CALIFORNIA (THE) 发明人 WILLIAMS, LEWIS T.;JOHNSON, DANIEL E.;LEE, PAULINE L.
分类号 A61K38/00;A01N;A61K38/04;A61P35/00;A61P43/00;C07K14/00;C07K14/47;C07K14/705;C07K14/71;C07K14/715;C07K16/28;C12N5/10;C12N15/09;C12N15/12;C12P;C12P21/02;C12P21/08;C12Q1/00;C12R1/91;G01N33/53;G01N33/577;G01N33/74;(IPC1-7):C12N15/18;C12N15/13;A61K39/395;G01N33/566 主分类号 A61K38/00
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