HYBRID MOLECULES

摘要

A hybrid molecule containing a hematopoietin receptor superfamily cytokine (or a fragment or analog thereof capable of binding to the high-affinity receptor for such cytokine) covalently bonded, at its amino terminal end, to a chemical entity which causes the hybrid molecule to be processed via a lower affinity receptor for such cytokine to a degree less than the degree of processing of the cytokine by the lower affinity receptor, provided that the chemical entity cannot be a fragment of diptheria toxin which includes the translocation domain of that toxin. APPL0685