发明名称 |
NOVEL RECOMBINANT AND CHIMERIC ANTIBODIES DIRECTED AGAINST A HUMAN ADENOCARCINOMA ANTIGEN |
摘要 |
The present invention comprises novel recombinant DNA compounds which encode monoclonal antibody KS1/4 and chimeric derivatives of monoclonal antibody KS1/4. Eukaryotic expression vectors have been constructed that comprise novel KS1/4-encoding DNA and drive expression of KS1/4 when transformed into an appropriate host cell. The novel expression vectors can be used to create modified and chimeric derivatives of KS1/4. The recombinant-produced KS1/4, KS1/4 derivatives and KS1/4 chimeras are useful for the diagnosis, prognosis and treatment of disease states including adenocarcinoma. |
申请公布号 |
ZA8902840(B) |
申请公布日期 |
1990.12.28 |
申请号 |
ZA19890002840 |
申请日期 |
1989.04.18 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
LISA SELSAM BEAVERS;THOMAS FRANK BUMOL;ROBERT ALAN GADSKI;BARBARA JEAN WEIGEL |
分类号 |
G01N33/574;A61K39/395;A61P35/00;C07K14/00;C07K16/00;C07K16/30;C07K16/46;C07K19/00;C12N15/13;C12P21/08;C12R1/91;G01N33/577 |
主分类号 |
G01N33/574 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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