| 摘要 |
<p>Dopamine agonist compounds useful in the treatment of hypertension and congestive heart failure in mammals are disclosed. The dopamine agonist compounds include racemic and non-racemic mixtures of chiral compounds as well as optically pure R,R; R,S and S,S stereoisomers which are all intended to be schematically described by the following general formula (I) <CHEM> wherein: R1 is independently hydrogen, lower alkyl, -C(O)R3, or -C(O)NR3R4, wherein R3 and R4 are independently lower alkyl, optionally substituted phenyl or phenyl lower alkyl; R2 is hydrogen or lower alkyl-, X is -(CH2)m- or -(CH2)nY(CH2)n-, where m is an integer from 1 to 10, n is an integer of 1 to 3, and Y is oxygen or sulfur; All of R1, and R2 are most preferably hydrogen, X is most preferably -(CH2)m- and the preferred optically pure R stereoisomer (most preferably R,R stereoisomer) of the dopamine agonist is preferably in the form of a pharmaceutically acceptable salt, preferably included in a dosage form with a suitable carrier.</p> |
